I try to play PLO8 tourneys, and I do ok but I think that's not because of any great skill on my part. I feel like I understand how to loosen my hand requirements in NLHE as there become fewer players, but not in PLO8.

How do I loosen up my starting hand requirements? What about post-flop? When does two pair become a good hand to bet?

Try and just get through the field with whatever situation and when the tables get a bit short near the end, take navybutton's advice.

he's said it about 1000 times:
something about raising most buttons/CO and then play from there.

i would be lying if i wasn't thinking that after reading the OP.

PLO and PLO8 tourneys: you can maybe open up early but do it in position and try to double through to accumulate a stack. this doesn't mean going crazy, but you can probably call a raise on the button w/ something like A3910. middle stages i play PLO and PLO8 tourneys WAY tighter than i play NLHE. there's nothing wrong with sitting on your hands and then going to the matt w/ aces or ABCD multi-way.

at the final table...well... i think 1000 times should be enough.