I've never used an illegal drug in my life, and even I think it's a lame suggestion. Also, from a strictly "+EV" point of view, who hasn't won significant pots off of opponents that were drunk? I say, as long as they don't vomit all over me or start fights, let 'em be on steroids, coke, heroin, weed, speed, super-size fries, and 10 pounds of sugar. More money for the rest of us.